General Information

  • ID:  hor004956
  • Uniprot ID:  P80677
  • Protein name:  Gonadoliberin-1
  • Gene name:  NA
  • Organism:  Chelyosoma productum (Solitary ascidian)
  • Family:  GnRH family
  • Source:  animal
  • Expression:  GNRH neurons lie within blood sinuses close to the gonoducts and gonads in both juveniles and adults, implying that the neuropeptide is released into the bloodstream.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Chelyosoma (genus), Corellidae (family), Phlebobranchia (order), Ascidiacea (class), Tunicata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QHWSDYFKPG
  • Length:  10
  • Propeptide:  QHWSDYFKPG
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the secretion of gonadotropins, luteinizing and follicle-stimulating hormones.
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004956_AF2.pdbhor004956_ESM.pdb

Physical Information

Mass: 142507 Formula: C60H77N15O16
Absent amino acids: ACEILMNRTV Common amino acids: DFGHKPQSWY
pI: 7.54 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 2
Hydrophobicity: -163 Boman Index: -2176
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: -1645 Extinction Coefficient cystines: 6990
Absorbance 280nm: 776.67

Literature

  • PubMed ID:  8816823
  • Title:  Two new forms of gonadotropin-releasing hormone in a protochordate and the evolutionary implications.